The bioavailability of those products is limited by their solvation rate.Example: glibenclamide, bicalutamide, ezetimibe, aceclofenac.Class II - high permeability, low solubility.Those compounds are well absorbed and their absorption rate is usually higher than excretion.Class I - high permeability, high solubility.BCS classes Īccording to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability: All those factors are highly important because 85% of the most sold drugs in the United States and Europe are orally administered. The intestinal permeability classification is based on a comparison to the intravenous injection. The solubility classification is based on a United States Pharmacopoeia (USP) aperture. This system restricts the prediction using the parameters solubility and intestinal permeability.
The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability.
For other uses of the abbreviation BCS, see BCS (disambiguation).
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